skip to content

Faculty of MedicineInstitute of Medical Statistics and Computational Biology

Univ.-Prof. Dr. rer. nat. Dipl.-Math.

Achim Tresch

Photo: at

 

 

Director

 

Head AG Computational Biology

Phone: +49(0)221 478 96512

E-Mail: achim.treschSpamProtectionuni-koeln.de

 

 

 

Research Focus

  • Transcription regulation, RNA metabolsm, Epigenomics
  • Statistical methods for the integration of high dimensional, biomedical data, in particular single cell omics technologies and high throughput microscopy
  • Probabilistic graphical models fort the reconstruction of signal transduction networks

 

Professional Career

2017 – today      Director, Institute of Medical Statistics and Computational Biology, Medical Faculty, University of Cologne

2012 – 2017       Jeff Schell Professor for Bioinformatics, Max Planck Institute for Plant Breeding Research, Cologne

2008 – 2012       Research group leader, Gene Center, Ludwig-Maximilians University, Munich

2006 – 2008       "Junior professor", Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), Johannes Gutenberg-University Mainz

2005 – 2006       Postdoc, German Cancer Research Center (DFKZ), Heidelberg

2002 - 2004        Postdoc, Fraunhofer Institut for Algorithms and Scientific Computing, St. Augustin

 

Education

1997 – 2001       PhD in Mathematics, Johannes Gutenberg-University Mainz

1991 – 1997       Diploma in Mathematics, Johannes Gutenberg-University Mainz

1991 – 1993       Intermediate diploma in Physics and Medicine, Johannes Gutenberg-University Mainz

 

Selected Publications

  • Schwalb, B, Margaux, M, Zacher B, Fühauf K, Demel K, Tresch A, Gagneur J, Cramer P. TT-seq maps the human transient transcriptome, Science 2016.
     
  • Niederberger T, Failmezger H, Uskat D, Poron D, Glauche I, Scherf N, Roeder  I, Schroeder T, Tresch, A. Factor graph analysis of live cell imaging data reveals mechanisms of cell fate decisions, Bioinformatics 2015.
     
  • Zacher B, Lidschreiber M, Cramer P, Gagneur J, Tresch A. Annotation of directed genomic states unveils variations in the Pol II transcription cycle, Molecular Systems Biology 2014.
     
  • Sun M, Schwalb B, Pirkl N, Maier K, Failmezger H, Tresch A, Cramer P. Global analysis of mRNA degradation reveals Xrn1-dependent buffering of transcript levels. Mol. Cell 2013.
     
  • Schmidt C, Bultmann S, Meilinger D, Zacher B, Tresch A, Maier K, Peter C, Martin D, Leonhardt H, Spada F. Global DNA hypomethylation prevents consolidation of differentiation programs and allows reversion to the embryonic stem cell state, PLoS One, 2012.
     
  • Gagneur J, Elze M, Tresch A. Selective phenotyping, Entropy Reduction and the Mastermind Game., BMC Bioinformatics 2011.
     
  • Beerenwinkel N, Knupfer P, Tresch A. Learning monotonic genotype-phenotype maps. Statistical Applications in Genetics and Molecular Biology 2011.
     
  • Miller C, Schwalb B, Maier K, Schulz D, Dümcke S, Zacher B, Mayer A, Sydow J, Marcinowski L, Dölken L, Martin D, Tresch A (co-correspondence), Cramer P. Dynamic transcriptome analysis reveals dynamics of mRNA synthesis and decay in yeast. Molecular Systems Biology, 2011.
     
  • Schneider E, Pliushch G, El Hajj N, Galetzka D, Puhl A, Schorsch M, Frauenknecht K, Riepert T, Tresch A, Müller A, Coerdt W, Zechner U, Haaf T. Spatial, temporal and inter- individual epigenetic variation of functionally important DNA methylation patterns. Nucleic Acids Research, 2010.